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Estudio densitométrico del tejido óseo neoformado por el uso de rhBMP-2 en mandíbulas de ratas Wistar / Optical densitometry study of the newly formed bone using rhBMP-2 in Wistar rat mandibles
Issa, Joáo Paulo Mardegan; Nascimento, Cássio do; Sato, Sandra; Barbosa, Rodrigo Edson Santos; Benetti, Emerson Toffanello; Albuquerque Junior, Rubens Ferreira de.
  • Issa, Joáo Paulo Mardegan; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
  • Nascimento, Cássio do; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
  • Sato, Sandra; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
  • Barbosa, Rodrigo Edson Santos; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
  • Benetti, Emerson Toffanello; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
  • Albuquerque Junior, Rubens Ferreira de; University of Sao Paulo. Faculty of Dentistry. Ribeirao Preto. BR
Int. j. morphol ; 25(2): 347-352, jun. 2007. ilus, tab
Article in Spanish | LILACS | ID: lil-495932
ABSTRACT
The purpose of this study was to evaluate the efficacy of monoolein gel as a carrier for rhBMP-2 in the healing bone process of critical bone defects created in Wistar rats mandibles using digitalized radiographic method to analyze this process. In the group 1, the rhBMP-2 was dissolved in aqueous solution and in the group 2, the rhBMP-2 was combined with monoolein gel as a carrier. The results showed that in both of groups it was found efficient bone repair, with a great optical density in the group that the rhBMP-2 was combined with the monoolein gel, but without statistical difference between them.
RESUMEN
El objetivo de este estudio fue evaluar la eficiencia del gel de monoolein como portador de la rhBMP-2 en el proceso de recuperación de la osificación en defectos osteos creados en mandíbulas de ratos Wistar, por medio de radiografias digitalizadas como método de análisis. En el grupo 1, la rhBMP-2 fue disuelta en solución acuosa y en el grupo 2, la rhBMP-2 fue combinada al gel de monoolein como portador. Los resultados mostraron que los dos grupos presentaron un eficiente reparo osteo, con mayor densidad óptica en el grupo en que la rhBMP-2 fue combinada con el gel de monoolein, pero sin diferencia estadística significante entre ellos.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Bone Regeneration / Recombinant Proteins / Transforming Growth Factor beta / Bone Morphogenetic Proteins / Mandible Limits: Animals Language: Spanish Journal: Int. j. morphol Journal subject: Anatomy Year: 2007 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: University of Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bone Regeneration / Recombinant Proteins / Transforming Growth Factor beta / Bone Morphogenetic Proteins / Mandible Limits: Animals Language: Spanish Journal: Int. j. morphol Journal subject: Anatomy Year: 2007 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: University of Sao Paulo/BR