Avaliação prospectiva do perfil lipídico na artrite reumatóide / Prospective evaluation of the lipid profile in rheumatoid arthritis

RESUMO

OBJETIVO: Avaliar a alteração do perfil lipídico na artrite reumatóide e sua associação com a atividade de doença. MÉTODOS: Estudo prospectivo de 21 pacientes, do sexo feminino, com artrite reumatóide, acompanhados durante um ano. Foram avaliados colesterol total, LDL-colesterol, HDL-colesterol, triglicérides, apolipoproteínas A e B, lipoproteína (a) e VHS, além de HAQ e índice de atividade de doença, por meio do DAS28. RESULTADOS: Após um ano, houve aumento significativo dos níveis de colesterol total (p = 0,019) em 66,6 por cento das pacientes e de LDL-colesterol (p = 0,008) em 80,9 por cento das pacientes. Quanto aos níveis de lipoproteína (a), houve redução significativa (p = 0,003) em 33,33 por cento dos casos. Diminuição significativa ocorreu também no VHS, HAQ e DAS28. Porém, não houve associação entre a alteração do perfil lipídico e a atividade de doença. CONCLUSÃO: Embora tenha sido significativa a redução da atividade da doença (DAS28), houve piora do perfil lipídico.

ABSTRACT

OBJECTIVE: To evaluate the lipid profile in rheumatoid arthritis and its association with the disease activity. METHODS: This was a prospective study with 21 female patients who had rheumatoid arthritis and whose progress was accompanied for 1 year. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoproteins A and B, lipoprotein (a), ESR, as well as HAQ and disease activity through DAS28, were evaluated. RESULTS: After 1 year, the total cholesterol level was increased in 66.6 percent of the patients (p=0.019) and the LDL-cholesterol level was also elevated in 80.9 percent of the patients (p=0.008). In contrast, the lipoprotein (a) level was reduced in 33.33 percent of the cases (p=0.003). A significant decrease also occurred in ESR, HAQ and DAS28. However, there was no association between the alteration of the lipid profile and the disease activity. CONCLUSION: Although the reduction in the disease activity (DAS28) was significant, the lipid profile worsened.