Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
Braz. j. infect. dis
;
12(4): 306-309, Aug. 2008. tab
Article
in English
| LILACS
| ID: lil-496768
ABSTRACT
Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5 percent (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response, based on multivariate analysis. The vaccination scheme of 40 mg at 0, 1 and 6 months was superior to conventional vaccination doses (20 mg) for cirrhotic patients on a waiting list for liver transplantation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis B Vaccines
/
Hepatitis B
/
Hepatitis B Surface Antigens
/
Liver Cirrhosis
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of São Paulo/BR
Similar
MEDLINE
...
LILACS
LIS