Anticuerpos anti-péptido citrulinado cíclico en artritis reumatoide, artritis psoriática y otras enfermedades / Anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis and psoriatic arthritis

ABSTRACT

The anti-cyclic citrullinated peptide (Anti-CCP) antibodies are actually the markers of highly specific recognize for rheumatoid arthritis (RA). Its presence in RA has been associated with higher disease clinical activity characterize by greater loss of function and development of erosive illness with important radiological damage. Furthermore, its production is an early process in RA development and because that, their presence is predictive for disease development. But in spite of the fact its high specificity, in the last years they also has been detected in other arthropathies diseases like psoriatic arthritis (PsA). Even if the prevalence of Anti-CCP in PsA reach values greater than expected for a disease different of AR, doesn`t reach statistical value, but its presence in this illness, like in AR, could might considerer a marker of disease severity, with development of aggressive clinic characteristics, polyarticular predominance, erosion presence and associated with shared epitope allele. The existing information don´t allow defining if this patience will develop more aggressive illness or existing concomitance of two joint diseases. More detail studies are necessary to defined that.