Reacciones adversas medicamentosas mucocutáneas en pacientes hospitalizados en servicio de medicina interna / Mucocutaneous adverse reactions to drugs in hospitalized patients of internal medicine service
Rev. chil. dermatol
;
23(2): 115-118, 2007. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-499206
RESUMEN
Las reacciones adversas medicamentosas mucocutáneas (RAMM) son una de las manifestaciones más frecuentes de reacción adversa a medicamentos. Su incidencia según datos internacionales alcanza un 2 por ciento a 3 por ciento en pacientes hospitalizados. Nosotros investigamos la incidencia de RAMM en el Servicio de Medicina Interna del Hospital Base de la ciudad de Los Ángeles. En el período junio-septiembre de 2006 se hospitalizaron 1.052 pacientes, diagnosticándose 3 casos de RAMM que representan un 0,3 por ciento. Se identificaron los fármacos atribuibles a las RAMM, correspondiendo a cloxacilina, toxoide tetánico y drogas antituberculosas; éstas se compararon posteriormente con un grupo control. Los casos identificados fueron un rash morbiliforme, una reacción inflamatoria local tipo celulitis y un rash urticariforme. La incidencia obtenida fue más baja de lo esperado, atribuyéndose a las características de atención del centro estudiado.
ABSTRACT
Mucocutaneous adverse reactions to drugs (MCRD) are one of the most frequent manifestations of adverse drug reaction. Its incidence, according to international data, reaches 2 to 3 percent in hospitalized patients. We studied the incidence of MCRD in the Internal Medicine Service of the Base Hospital, located in the city of Los Angeles, Chile. 1,052 patients were hospitalized during the June-September 2006 period, and three cases of MCRD were diagnosed, representing 0.3 percent. The drugs causing to MCRD were cloxacilin, tetanic toxoid and antituberculosis drugs; these were later compared to a control group. The identified cases were morbiliform rash, a cellulitis-type local inflammatory reaction, and urticariform rash. The obtained incidence was lower than expected, attributed to the characteristics of the studied center.
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Index:
LILACS (Americas)
Main subject:
Pharmaceutical Preparations
/
Drug Eruptions
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. chil. dermatol
Journal subject:
Dermatology
Year:
2007
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Víctor Ríos Ruiz/CL
/
Universidad San Sebastián/CL
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