Avaliação das metaloproteinases de matriz -2 e -9 em gatos com desmineralização óssea secundária à tirotoxicose induzida / Evaluation of matrix metalloproteinases -2 and -9 in cats under bone demineralization secondary to induced thyrotoxicosis
Arq. bras. med. vet. zootec
;
60(5): 1053-1060, out. 2008. ilus, graf, tab
Article
in Portuguese
| LILACS
| ID: lil-500069
RESUMO
Observou-se significativo aumento de atividade das formas ativas das metaloproteinases -2 e -9 em gatos com tirotoxicose induzida e desmineralização óssea. As formas pró e intermediária da metaloproteinase -2 elevaram-se com 14 dias de administração hormonal, porém, posteriormente, houve uma tendência de queda. Observou-se correlação negativa entre a forma ativa das metaloproteinases de matriz -2 e -9 e a densidade mineral óssea da extremidade distal do rádio. Os resultados sugerem aumento da degradação da matriz colágena secundária com a elevação dos hormônios tiroidianos.
ABSTRACT
Significant increase of activity of active forms of matrix metalloproteinases -2 and -9 in cats under induced thyrotoxicosis and bone demineralization was observed. Pro and intermediated forms of matrix metalloproteinases -2 and -9 increased at 14 days of hormonal treatment, followed by decrease tendency. A negative correlation between active forms of matrix metalloproteinases -2 and -9 and bone mineral density of radius distal extremity was also observed. The results suggest an increase of collagen matrix degradation secondary to high levels of thyroid hormones.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cats
/
Bone Demineralization, Pathologic
/
Matrix Metalloproteinases
/
Hyperthyroidism
Limits:
Animals
Language:
Portuguese
Journal:
Arq. bras. med. vet. zootec
Journal subject:
Veterinary Medicine
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFES/BR
/
UNESP/BR
/
UNESPAR/BR
/
UNICAMP/BR
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