Estudios citogenéticos en niños con Leucemia Linfocitica Aguda-B en Costa Rica / Cytogenetic studies in children with Acute Lymphocitic Leukemia-B in Costa Rica

ABSTRACT

Chromosome analyses were performed on bone marrow of 177 pediatric patients with Acute Lymphocitic Leukemia at the [quot ]Hospital Nacional de Nifios[quot ]. The standard cytogenetic techniques now belongs to the panel of mandatory analyses performed at diagnosis of our acute leukemia patients and represent a major advantage to be effective and independent prognostic factors, essential for therapeutic choices. Cytogenetic results were achieved in 83% of the bone marrow samples normal karyotypes represented 29% and abnormal karyotypes 71% with the follow distribution t (9;22) 3%; t (l;19) 5%; t (4;11) 3%, Hyperdiploidy 39%; other chromosomal abnormalities 21%. Systematic cytogenetic analyses are essencial to define morpho-immunologic sub-types of leukemia and to detect new translocations that allows to understand hematopoiesis and leukemogenesis.