Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Mem. Inst. Oswaldo Cruz
;
103(8): 773-777, Dec. 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-502296
ABSTRACT
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.
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Index:
LILACS (Americas)
Main subject:
Terpenes
/
Leishmania braziliensis
/
Cyclohexenes
/
Amino Alcohols
/
Antiprotozoal Agents
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2008
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
/
Universidade Federal do Rio Grande do Sul/BR
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