Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis / Produção de actinomicina-D por um mutante de uma nova cepa de Streptomyces sindenensis
Braz. j. microbiol
;
39(4): 689-692, Dec. 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-504308
ABSTRACT
An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400 percent higher actinomycin-D production was isolated (400 mg/l-1 as compared to 80 mg/l-1 produced by the parent). Production medium was optimized and antibiotic yield with the mutant was enhanced to 850 mg/l-1 which is 963 percent higher as compared with the parent.
RESUMO
Uma cepa produtora de actinomicina-D foi isolada de solo e caracterizada como Streptomyces sindenensis. A cultura foi submetida à radiação UV, e um mutante capaz de produzir 400 por cento mais actinomicina-D foi isolado (400mg/L comparado a 80mg/L produzido pela cepa parental). O meio de produção do antibiótico foi otimizado e o rendimento aumentou para 850 mg/L, ou seja, 963 por cento mais alto que a cepa parental.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Radiation
/
Streptomyces antibioticus
/
Dactinomycin
/
Anti-Bacterial Agents
/
Mutagens
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2008
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Central Drug Research Institute/IN
/
University of Lucknow/IN
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