Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
Braz. j. infect. dis
;
12(5): 395-399, Oct. 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-505353
ABSTRACT
We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Candida
/
Candidiasis
/
Cross Infection
/
Disease Outbreaks
/
Fungemia
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2008
Type:
Article
Affiliation country:
Japan
/
Turkey
Institution/Affiliation country:
Gazi University/TR
/
Meiji Pharmaceutical University/JP
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