Focal adhesion kinase signaling in cardiac hypertrophy and failure
Braz. j. med. biol. res
;
42(1): 44-52, Jan. 2009. ilus
Article
in English
| LILACS
| ID: lil-505421
ABSTRACT
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cardiomegaly
/
Myocytes, Cardiac
/
Focal Adhesion Protein-Tyrosine Kinases
/
Fibroblasts
/
Heart Failure
Type of study:
Etiology study
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2009
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Campinas/BR
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