Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
Braz. j. med. biol. res
;
42(2): 148-154, Feb. 2009. ilus
Article
in English
| LILACS
| ID: lil-506882
ABSTRACT
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Avoidance Learning
/
NF-kappa B
/
NG-Nitroarginine Methyl Ester
/
Memory
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2009
Type:
Article
/
Congress and conference
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR
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