Your browser doesn't support javascript.
loading
Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones / Adverse reactions to diphtheria-pertussis-tetanus vaccine in the Chilean Immunization Program
Abarca V, Katia; Cerda L, Jaime; Ferreccio R, Catterina.
  • Abarca V, Katia; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamentos de Pediatría. Santiago. CL
  • Cerda L, Jaime; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamentos de Salud Pública. Santiago. CL
  • Ferreccio R, Catterina; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamentos de Salud Pública. Santiago. CL
Rev. méd. Chile ; 137(1): 10-17, ene. 2009. tab
Article in Spanish | LILACS | ID: lil-511838
ABSTRACT

Background:

During 2005, the surveillance system of the Chilean Immunization Program detected an increased number of adverse reaction notifications associated to diphtheria, pertussis and tetanus whole-cell vaccine (DPT), coincidentiy with a change in the vaccine manufacturer.

Aim:

To compare the reactogenicity of two DPT formulations (vaccines 1 and 2) in 18-month-old infants and 4-year-old children. Material and

methods:

Severe adverse reactions to DPT were studied at the emergency room of two hospitals of Santiago in a case-control study (110 cases and 171 controls, who consulted for other causes). Simultaneously the incidence of total adverse reactions (mild and severe) for vaccine 1 and 2 was estimated in a cohort of 1,017 children vaccinated in an ambulatory health center of the same área. The formulation of DPT received by all participants was verífied, as well as the temporal relation with consultation or symptoms referred by their caregivers.

Results:

There was a greater probability of consulting at the emergency rooms for severe adverse reactions among children who received vaccine 1 (odds ratio (OR) =7.1; p <0.001), being greater among 4-year-old children (OR =18.9; p <0.001). Coincidentiy, in the cohort of vaccinated children, those who received vaccine 1 had a higher risk of presenting adverse reactions (RR =2.9; p <0.001), being high fever the commonest.

Conclusions:

We confirmed that vaccine 1 was associated to a higher risk of adverse reactions, especially among 4-year-old children. These results allowed the sanitary authority to adopt an informed decisión. The usefulness of observational studies in vaccine adverse reactions is confirmed.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Tetanus / Diphtheria-Tetanus-Pertussis Vaccine / Whooping Cough / Adverse Drug Reaction Reporting Systems / Immunization Programs / Diphtheria Type of study: Incidence study / Observational study / Prognostic study / Risk factors / Screening study Limits: Humans Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2009 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: LILACS (Americas) Main subject: Tetanus / Diphtheria-Tetanus-Pertussis Vaccine / Whooping Cough / Adverse Drug Reaction Reporting Systems / Immunization Programs / Diphtheria Type of study: Incidence study / Observational study / Prognostic study / Risk factors / Screening study Limits: Humans Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2009 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL