Polimorfismo genético de interleuquina-1: Asociación con cáncer gástrico en la población de alto riesgo del Centroccidente de Venezuela / lnterleukin-1 genetic polymorphism: Association with gastric cancer in the high-risk Central-Western population of Venezuela
Rev. méd. Chile
;
137(1): 63-70, ene. 2009. tab
Article
in Spanish
| LILACS
| ID: lil-511845
ABSTRACT
Background:
Genetic predisposition may play a role in the prevalence of gastric cancer (GC).Aim:
To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths. Material andmethods:
In a case-control study, we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.Results:
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in alogistic regression analysis, a significant association emerged for the IL- 1B+3954C carrier genotype (odds ratio (OR) 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR 7.0; 95% CI 2.3-21.5). Only patients with awell/moderately-differentiated adenocarcinoma that were homozygotes for the IL-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.Conclusions:
IL-IRN*2/*2 genotype is associated with increased risk of gastriccancer in the Venezuelan population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Stomach Neoplasms
/
Adenocarcinoma
/
Interleukin-1
/
Genetic Predisposition to Disease
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Venezuela
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Venezuela
Institution/Affiliation country:
UCLA/VE
/
Universidad Centroccidental Lisandro Alvarado/VE
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