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Positive effects of Green Tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium
Hamden, Khaled; Carreau, Serge; Ayadi Marki, Fatma; Masmoudi, Hatem; El Feki, Abdelfattah.
  • Hamden, Khaled; Faculty of Sciences. Animal Ecophysiology. Sfax. TN
  • Carreau, Serge; University of Caen. Biochemistry. FR
  • Ayadi Marki, Fatma; CHU H. Bourguiba. Biochemistry laboratory. Sfax. TN
  • Masmoudi, Hatem; CHU H. Bourguiba. Immunology laboratory. Sfax. TN
  • El Feki, Abdelfattah; Faculty of Sciences. Animal Ecophysiology. Sfax. TN
Biol. Res ; 41(3): 331-339, 2008. graf
Article in English | LILACS | ID: lil-511922
ABSTRACT
Cadmium (Cd) is a highly toxic environmental and industrial cumulative pollutant that affects many organs,especially the liver. The present study was designed to evaluate the antioxidant effect of green tea oncadmium-induced hepatic dysfunction and oxidative stress in rats. Adult male Wistar rats were administeredcadmium by injection of 20 ìmoles /kg bw/ every 3 days for six months. This study revealed significant (p <0.05) liver dysfunction, lipid peroxidation and a decline in antioxidant enzyme activities in the liver of cadmium-treated rats compared to control animals. Compared to control rats, the activities of lactate dehydrogenase (LDH), gammaglutamyl transferase (GGT), acid phosphatase (PAC), phosphatase alkaline (PAL), as well as bilirubin and thiobarbituric acid-reactive substances (TBARs), were significantly (p < 0.05)increased in Cd-treated rats. Moreover, antioxidant enzyme activities, such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase, were significantly (p < 0.05) decreased in the liver of cadmiumtreatedrats. The oral administration of 5% aqueous green tea extract, along with cadmium treatment for six months, caused a significant (p < 0.05) improvement in cadmium-induced toxicity by significantly decreasing(p < 0.05) the activities of enzymatic markers of liver dysfunction (LDH, GGT, PAC, PAL activities, as well as the bilirubin rate). Indeed, green tea extract significantly increased (p < 0.05) antioxidant enzymatic activities (SOD, Catalase, GPX) in rat liver, compared to those given cadmium alone. Thus, the oral administration of green tea, along with cadmium significantly (p < 0.05) improves cadmium-induced liverdysfunction and stress oxidant in rats’ liver.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Tea / Cadmium / Lipid Peroxidation / Camellia sinensis / Liver Diseases / Antioxidants Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2008 Type: Article Affiliation country: France / Tunisia Institution/Affiliation country: CHU H. Bourguiba/TN / Faculty of Sciences/TN / University of Caen/FR

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Full text: Available Index: LILACS (Americas) Main subject: Tea / Cadmium / Lipid Peroxidation / Camellia sinensis / Liver Diseases / Antioxidants Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2008 Type: Article Affiliation country: France / Tunisia Institution/Affiliation country: CHU H. Bourguiba/TN / Faculty of Sciences/TN / University of Caen/FR