Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease
Genet. mol. biol
;
32(2): 260-263, 2009. tab
Article
in English
| LILACS
| ID: lil-513959
ABSTRACT
We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83 percent in relation to individuals carrying the G/G genotype (OR = 0.172, 95 percent CI 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2009
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
The Affiliated ZhongDa Hospital of Southeast University/CN
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