Your browser doesn't support javascript.
loading
Characterization analysis and polymorphism detection of the porcine Myd88 gene
Li, Xinyun; Liu, Huazhen; Yang, Shulin; Tang, Zhonglin; Ma, Yuehui; Chu, Mingxing; Li, Kui.
  • Li, Xinyun; Ministry of Education of China. Huazhong Agricultural University. The Key Laboratory of Animal Genetics, Breeding and Reproduction. Wuhan. CN
  • Liu, Huazhen; Ministry of Education of China. Huazhong Agricultural University. The Key Laboratory of Animal Genetics, Breeding and Reproduction. Wuhan. CN
  • Yang, Shulin; Ministry of Agriculture of China. Institute of Animal Science. The Key Laboratory for Farm Animal Genetic Resources and Utilization. Beijing. CN
  • Tang, Zhonglin; Ministry of Agriculture of China. Institute of Animal Science. The Key Laboratory for Farm Animal Genetic Resources and Utilization. Beijing. CN
  • Ma, Yuehui; Ministry of Agriculture of China. Institute of Animal Science. The Key Laboratory for Farm Animal Genetic Resources and Utilization. Beijing. CN
  • Chu, Mingxing; Ministry of Agriculture of China. Institute of Animal Science. The Key Laboratory for Farm Animal Genetic Resources and Utilization. Beijing. CN
  • Li, Kui; Ministry of Agriculture of China. Institute of Animal Science. The Key Laboratory for Farm Animal Genetic Resources and Utilization. Beijing. CN
Genet. mol. biol ; 32(2): 295-300, 2009. ilus, graf, tab
Article in English | LILACS | ID: lil-513969
ABSTRACT
The myeloid differentiation primary response protein 88 (Myd88) is an essential adaptor protein, which mediates in all Toll-like receptor (TLR) members signal transduction, except for TLR3. In this study, the 4464 bp genomic sequence of porcine Myd88 was first isolated, whereupon tissue distribution, chromosome mapping and single nucleotide polymorphism (SNP) were analyzed. Our results revealed that porcine Myd88 gene, which was located at chromosome 13 linked with marker S0288 (distance = 40 cR; LOD = 8.66), was widely expressed in all the examined tissues. There were 16 potential SNPs in the isolated genome fragment. SNP 797T/C in the first intron was studied, with no significant association being found between the genotype and immune traits in pigs (p > 0.05). The porcine Myd88 protein contained both the death domain (DD) and the Toll/IL-1 receptor domain (TIR). Leu residues, essential for its structure, were the most abundant encountered in the DD. The TIR contained two conserved motifs which may play important roles in the Myd88 function.

Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2009 Type: Article Affiliation country: China Institution/Affiliation country: Ministry of Agriculture of China/CN / Ministry of Education of China/CN

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2009 Type: Article Affiliation country: China Institution/Affiliation country: Ministry of Agriculture of China/CN / Ministry of Education of China/CN