Urinary fluoride output in children following the use of a dual-fluoride varnish formulation
J. appl. oral sci
; 17(3): 179-183, May-June 2009. graf, tab
Article
in En
| LILACS
| ID: lil-514029
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
This study evaluated the bioavailability of fluoride after topical application of a dual-fluoride varnish commercially available in Brazil, when compared to DuraphatTM. MATERIAL ANDMETHODS:
The urinary fluoride output was evaluated in seven 5-year-old children after application of the fluoride varnishes, in two different phases. In the first phase (I), children received topical application of the fluoride varnish Duofluorid XII (2.92 percent fluorine, calcium fluoride + 2.71 percent fluorine, sodium fluoride, FGM TM). After 1-month interval (phase II), the same amount (0.2 mL) of the fluoride varnish Duraphat (2.26 percent fluorine, sodium fluoride, ColgateTM) was applied. Before each application all the volunteers brushed their teeth with placebo dentifrice for 7 days. Urinary collections were carried out 24 h prior up to 48 h after the applications. Fluoride intake from the diet was also estimated. Fluoride concentration in diet samples and urine was analyzed with the fluoride ion-specific electrode and a miniature calomel reference electrode coupled to a potentiometer. Data were tested by ANOVA and Tukey's post hoc test (p<0.05).RESULTS:
There were significant differences in the urinary fluoride output between phases I and II. The use of Duofluorid XII did not significantly increase the urinary fluoride output, when compared to baseline levels. The application of Duraphat caused a transitory increase in the urinary fluoride output, returning to baseline levels 48 h after its use.CONCLUSIONS:
The tested varnish formulation, which has been shown to be effective in in vitro studies, also can be considered safe.Key words
Full text:
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Index:
LILACS
Main subject:
Sodium Fluoride
/
Cariostatic Agents
/
Fluorides, Topical
/
Fluorides
Type of study:
Clinical_trials
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
J. appl. oral sci
Journal subject:
ODONTOLOGIA
Year:
2009
Type:
Article