Oral clefts, consanguinity, parental tobacco and alcohol use: a case-control study in Rio de Janeiro, Brazil
Braz. oral res
;
23(1): 31-37, 2009. tab
Article
in English
| LILACS
| ID: lil-514639
ABSTRACT
This hospital-based, case-control study investigated the possible associations between family history of malformations, parental consanguinity,smoking and alcohol drinking and nonsyndromic orofacial cleft (OC, subdivided in 2 main groups CL/P - cleft lip with or without cleft palate and CP - cleft palate alone). 274 cases were matched (age, sex and place of residence) to 548 controls. Odds ratios (OR) and 95% confi dence intervals (95% CI) adjusted for maternal age, schooling and smoking / alcohol use were calculated by conditional logistic regression. The results demonstrated that the history of oral clefts either in thefathers (CL/P OR = 16.00, 5.64- 9.23; CP OR = 6.64, 1.48-33.75) or in the mothers family (CL/P OR = 5.00, 2.31-10.99, CP OR = 12.44, 1.33-294.87) was strongly associated with both types of clefts, but parental consanguinity was associated only with CL/P (OR = 3.8, 1.27-12.18). Prevalence of maternal smoking during the fi rst trimester of pregnancy was higher among cases but the OR (1.13, 0.81-1.57) was not statistically signifi cant. Maternal passive smoking (nonsmoking mothers) during pregnancy was associated with CL/P (1.39, 1.01-1.98) but not with CP.Maternal alcohol use during the 1st trimester increased odds for CL/P (OR = 2.08, 1.27-3.41) and CP (OR = 2.89, 1.25-8.30), and odds for OC tended to increase with dose. Neither smoking nor alcohol use by fathers increased risks for OC. This study provides further evidence of a possible role of maternal exposure to tobacco smoke and alcohol in the etiology of nonsyndromic oral clefts.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prenatal Exposure Delayed Effects
/
Alcohol Drinking
/
Smoking
/
Cleft Lip
/
Cleft Palate
/
Consanguinity
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. oral res
Journal subject:
Dentistry
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Juiz de Fora/BR
/
Ministry of Health/BR
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