Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy
Int. braz. j. urol
;
35(2): 183-189, Mar.-Apr. 2009. tab
Article
in English
| LILACS
| ID: lil-516960
ABSTRACT
PURPOSE:
Preexisting bone loss in men with prostate cancer is an important issue due to the accelerated bone loss during androgen deprivation therapy (ADT). In addition, a high prostate-specific antigen (PSA) level has been reported to be related to bone metabolism. This study assessed the factors associated with osteoporosis in Korean men with non-metastatic prostate cancer before undergoing ADT. MATERIAL ANDMETHODS:
The study enrolled patients admitted for a prostate biopsy because of a high PSA or palpable nodule on a digital rectal examination. We divided the patients (n = 172) according to the results of the biopsy group I, non-metastatic prostate cancer (n = 42) and group II, benign prostatic hypertrophy (BPH; n = 130). The lumbar bone mineral density (BMD) was evaluated using quantitative computed tomography. The demographic, health status, lifestyle, body mass index (BMI), serum testosterone concentration, and disease variables in prostate cancer (Gleason score, clinical stage, and PSA) were analyzed prospectively to determine their effect on the BMD.RESULTS:
The estimated mean T-score was higher in group I than in group II (-1.96 ± 3.35 vs. -2.66 ± 3.20), but without statistic significance (p = 0.235). The significant factors correlated with BMD in group I were a high serum PSA (ß = -0.346, p = 0.010) and low BMI (ß = 0.345, p = 0.014) in the multiple linear regression model. Also old age (r = -0.481, p = 0.001), a high serum PSA (r = -0.571, p < 0.001), low BMI (r = 0.598, p < 0.001), and a high Gleasons score (r = -0.319, p = 0.040) were the factors related to BMD in the correlation. The significant factors correlated with BMD in group II were old age (ß = -0.324, p = 0.001) and BMI (ß = 0.143, p = 0.014) in the multiple linear regression model.CONCLUSIONS:
The risk factors for osteoporosis in men with prostate cancer include a low BMI, and elevated serum PSA. Monitoring BMD from the outset of ADT is a logical first...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoporosis
/
Prostatic Neoplasms
/
Bone Density
/
Prostate-Specific Antigen
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Aged80
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2009
Type:
Article
Affiliation country:
South Korea
Institution/Affiliation country:
Chonnam National University Medical School/KR
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