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A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience
Macedo Júnior, Antonio; Rosito, Tiago; Pires, Jesus A. S; Liguori, Riberto; Ortiz, Valdemar.
  • Macedo Júnior, Antonio; Federal University of Sao Paulo. Department of Urology. Sao Paulo. BR
  • Rosito, Tiago; Federal University of Sao Paulo. Department of Urology. Sao Paulo. BR
  • Pires, Jesus A. S; Federal University of Sao Paulo. Department of Urology. Sao Paulo. BR
  • Liguori, Riberto; Federal University of Sao Paulo. Department of Urology. Sao Paulo. BR
  • Ortiz, Valdemar; Federal University of Sao Paulo. Department of Urology. Sao Paulo. BR
Int. braz. j. urol ; 35(2): 205-216, Mar.-Apr. 2009. ilus, tab
Article in English | LILACS | ID: lil-516962
ABSTRACT

INTRODUCTION:

The appendix is the gold-standard channel for the Mitrofanoff principle in pediatric urology, but the search for alternatives is justified considering it may not be available or preferably used for colonic stomas (Malone antegrade continence enema). The aim of this study is to report on technical feasibility of a new approach for creating catheterizable channels in a rabbit model and to present our preliminary clinical experience. MATERIAL AND

METHODS:

We configured a tube from two rectangular skin flaps 1x4 cm opposite each other in the middle line of the lower inferior abdomen. The channel was anastomosed to the bladder dome with embedding sutures to create a valvular mechanism. The experimental study consisted of 12 rabbits, divided in 4 groups according to the sacrifice schedule at 2, 4, 8 and 12 weeks. At 30th postoperative day, an urodynamic evaluation was performed to record continence of the stoma. A histological analysis of the specimens stained with hematoxylin-eosin, Masson trichrome and Picrosirius red was also done in group 2 (sacrifice at 4 weeks postoperatively). We used this method in 3 patients with congenital non-neurogenic bladder disease presenting with massive residual volumes without compliance deficits.

RESULT:

The technique proved feasible in all animals, 9 of 12 could be easily catheterized and underwent urodynamic study. No stoma leakage was observed in 7 animals at high bladder pressures (> 50 cm H20) and only 2 animals had some leakage at 40 cm H20. Urodynamics performed through the stoma showed urethral leakage at 20 cm H20, therefore demonstrating the efficacy of the valvular mechanism. Histological analysis confirmed good integration between the tube and the bladder. Mean follow-up of the clinical series (3 patients) was 7.2 months. Two patients remained continent up to 4 hours, whereas 1 patient had some leakage after 2 hours.

CONCLUSION:

We were able to confirm feasibility of a new extra-abdominal...
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Appendix / Urinary Bladder Diseases / Cystostomy / Urinary Reservoirs, Continent Type of study: Observational study / Prognostic study Limits: Animals / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Appendix / Urinary Bladder Diseases / Cystostomy / Urinary Reservoirs, Continent Type of study: Observational study / Prognostic study Limits: Animals / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Sao Paulo/BR