RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
Mem. Inst. Oswaldo Cruz
;
104(3): 441-443, May 2009. ilus, graf
Article
in English
| LILACS
| ID: lil-517008
ABSTRACT
This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8 percent) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Mycobacterium tuberculosis
Country/Region as subject:
Asia
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Madagascar
/
Mauritius
/
Norway
Institution/Affiliation country:
Institut Pasteur de Madagascar/MG
/
Ministry of Health and Quality of Life/MU
/
Norwegian Institute of Public Health/NO
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