Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
J. venom. anim. toxins incl. trop. dis
;
15(2): 236-254, 2009. graf
Article
in English
| LILACS
| ID: lil-517293
ABSTRACT
TsTX is an á-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extracellular levels in the hippocampus; however, levels of gamma-aminobutyric acid (GABA), glycine, 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were not significantly altered. Neurodegeneration in pyramidal cells of hippocampus and electroencephalographic alterations caused by the toxin were blocked by pretreatment with riluzole, a glutamate release inhibitor. The present results suggest a specific activity of TsTX in the hippocampus which affects only glutamate release.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Scorpion Venoms
/
Neurotransmitter Agents
/
Hippocampus
Limits:
Animals
/
Humans
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Butantan Institute/BR
/
University of São Paulo/BR
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