A study of iga antibody response to different mycobacterium tuberculosis antigens in the diagnosis and monitoring of pulmonary tuberculosis
Braz. j. infect. dis
;
13(1): 53-58, Feb. 2009. graf, tab
Article
in English
| LILACS
| ID: lil-517815
ABSTRACT
We evaluated the performance of the ELISA technique in the detection of IgA antibodies against different Mycobacterium tuberculosis antigenic preparations in serum samples from 49 patients with pulmonary tuberculosis collected before and after the start of specific treatment. The controls consisted of serum samples from healthy patients without any prior contact with the bacteria and serum samples from patients with other pneumopathies. Glycolipid antigen gave the best diagnostic performance, with a sensitivity of 88 percent and specificities varying from 88 to 100 percent in the control groups. These antigens constitute a powerful tool for the diagnosis and monitoring of patients with pulmonary tuberculosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis, Pulmonary
/
Immunoglobulin A
/
Antibodies, Bacterial
/
Mycobacterium tuberculosis
/
Antigens, Bacterial
Type of study:
Diagnostic study
/
Evaluation studies
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Maranhão/BR
/
Federal University of Santa Maria/BR
/
São Paulo Institute of Tropical Medicine/BR
/
University of São Paulo/BR
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