Trastorno linfoproliferativo post trasplante renal en un niño / Lymphoproliferative disorders after renal transplantation in a child
Rev. méd. Chile
;
137(3): 405-410, mar. 2009. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-518502
ABSTRACT
Post transplant lymphoproliferative disorder (PTLD) is the commonest form of post transplant malignancy in children. The incidence in renal transplant recipients varies between 2 percent-4 percent. They are characterized by uncontrolled B lymphocyte proliferation, in most cases driven by Epstein Barr virus (EBV). They are more common in younger children, EBV seronegative patients and those who receive aggressive immunosuppression. PTLD commonly presents in an unspecific form and it requires high suspicion rate for its diagnosis, especially in children with risk factors. We report a twelve year-old girl who developed fever, sore throat and lymph node enlargement, six months after receiving a renal allograft. Laboratory assessment and imaging studies were compatible with PTLD, which was confirmed by biopsy. Treatment was reduction of immunosuppression and surveillance. The patient had a favorable evolution.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Kidney Transplantation
/
Sirolimus
/
Immunosuppressive Agents
/
Lymphoproliferative Disorders
Type of study:
Risk factors
Limits:
Child
/
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2009
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
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