Hepatoprotective effect of Cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats
Biol. Res
;
42(1): 93-98, 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-519087
ABSTRACT
Cinnamon is used to flavor most foods in Arabian countries. The aim of this study was to evaluate the medicinal importance, reflecting an important trend in research. The hepatoprotective activity of aqueous and ethanolic extracts of cinnamon was investigated against carbon tetrachloride (CC1(4)) induced lipid peroxidation and hepatic injury in rats. The elevated serum AST and ALT enzymatic activities induced by CC1(4) were significantly restored to near normal by oral administration of 200 mg/kg of either extracts once daily for 7 days, as compared to untreated rats. There was a significant elevation in the level of liver malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in CC1(4) intoxicated rats. The results obtained indicated that ethanolic extract has more potent hepatoprotective action than water extract against CC1(4) by lowering the MDA level and elevating antioxidants enzymes activities (SOD and CAT). The possible mechanism of this activity may be free radical-scavenging polyphenol compounds. The hepatoprotective properties were documented by the histopathological data obtained. Consequently, this extract can be used as a therapeutic regime in treatment of some hepatic disorders without any side effects. Further study will be done for separation and identification of active components and for testing antitumor activity.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Cinnamomum zeylanicum
/
Oxidative Stress
/
Liver
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2009
Type:
Article
Affiliation country:
Egypt
Institution/Affiliation country:
Ain Shams University/EG
/
Alexandria University/EG
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