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The possible role of Myosin light chain in myoblast proliferation
Su-Zhen, Zhang; Young, Xu; Hui-Qi, Xie; Xiu-Qun, Li; Yu-Quan, Wei; Zhi-Ming, Yang.
  • Su-Zhen, Zhang; Sichuan University. West China Medical School and School of Life Science. West China Hospital. Division of Stem Cell and Tissue Engineering. Chengdu. CN
  • Young, Xu; Sichuan University. West China Medical School and School of Life Science. West China Hospital. State Key Laboratory of Biotherapy. Chengdu. CN
  • Hui-Qi, Xie; Sichuan University. West China Medical School and School of Life Science. West China Hospital. Division of Stem Cell and Tissue Engineering. Chengdu. CN
  • Xiu-Qun, Li; Sichuan University. West China Medical School and School of Life Science. West China Hospital. State Key Laboratory of Biotherapy. Chengdu. CN
  • Yu-Quan, Wei; Sichuan University. West China Medical School and School of Life Science. West China Hospital. State Key Laboratory of Biotherapy. Chengdu. CN
  • Zhi-Ming, Yang; Sichuan University. West China Medical School and School of Life Science. West China Hospital. Division of Stem Cell and Tissue Engineering. Chengdu. CN
Biol. Res ; 42(1): 121-132, 2009. ilus
Article in English | LILACS | ID: lil-519091
ABSTRACT
Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this report, we studied the possible role of Myl in the proliferation of skeletal muscle-derived myoblasts. Compared to diaphragm-derived myoblasts, the extraocular muscle-derived myoblasts with lower levels of Myl proliferated faster, maintained a longer proliferation phase, and formed more final myotubes. It was found that blockading Myl with anti-Myl antibody or knockdown of Myll by siRNA targeted against Myll could enhance the myoblast proliferation and delay the differentiation of myoblasts. Our results suggested that Myl, likely Myll, can negatively affect myoblast proliferation by facilitating myoblast withdrawal from cell cycle and differentiation.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Regeneration / Diaphragm / Myosin Light Chains / Myoblasts / Cell Proliferation / Oculomotor Muscles Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2009 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Sichuan University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Regeneration / Diaphragm / Myosin Light Chains / Myoblasts / Cell Proliferation / Oculomotor Muscles Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2009 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Sichuan University/CN