The importance of apoptosis for immune regulation in Chagas disease
Mem. Inst. Oswaldo Cruz
;
104(supl.1): 259-262, July 2009.
Article
in English
| LILACS
| ID: lil-520887
ABSTRACT
Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.
Full text:
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Chagas Disease
/
Apoptosis
/
Host-Parasite Interactions
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR
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