Protective immunity against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
104(supl.1): 288-294, July 2009. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-520891
ABSTRACT
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi reservoirs that sought to address practical vaccination problems. Research on the maturation of memory cells and studies indicating that the prevalence of T. cruzi-specific T-cell responses and a high frequency of committed CD8+ T cells are associated with better clinical outcomes are also reviewed. Additionally, animal models in which protection was achieved without immunopathological consequences are discussed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antibodies, Protozoan
/
Protozoan Vaccines
/
Chagas Disease
Type of study:
Risk factors
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Salta/AR
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