Asociación de la variante GHRd3 del receptor de la hormona de crecimiento con autoinmunidad en la diabetes tipo 1 / Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes
Rev. méd. Chile
;
137(5): 609-616, mayo 2009. tab, graf
Article
in Spanish
| LILACS
| ID: lil-521862
ABSTRACT
Background:
Growth Hormone Receptor (GRH) is expressed in the liver, pancreas, stomach and small intestine. A high expression of GHR mRNA in the mucosal gut suggests a possible role of this receptor on digestive and immune functions.Aim:
To investigate the putative effects of the GHRd3 variants on the cytokine profile and distribution of auto-antibodies in children with type 1 diabetes (T1D). Material andMethods:
Unrelated unaffected controls (n =192) and incident cases of children with T1D (n =127) were analyzed for GHRd3 polymorphism, cytokine profile and a panel of auto-antibodies.Results:
The allele frequency for d3 was 24.8 percent in type 1 diabetics and 34.1 percent in controls (p =NS). Among type 1 diabetic children, the carriers of the GHRd3 polymorphism had significantly higher levels of interleukin-lB than homozygous for the wild type genotype (5.7 and 17.7, pg/ml respectively p <0.015). Carriers of d3 variant had a higher frequency of positive anti-insulin antibodies (anti-IAA) than children without this variant (39.6 and 17.7 percent respectively, p <0.01).Conclusions:
The observed frequency of the GHR d3/d3 genotype was comparable to other reports. A relationship between d3 variant and anti-IAA antibodies and interleukin-1ß was observed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Autoantibodies
/
Receptors, Somatotropin
/
Autoimmunity
/
Cytokines
/
Diabetes Mellitus, Type 1
/
Insulin Antibodies
Type of study:
Observational study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Hospital San Juan de Dios/CL
/
Universidad de Chile/CL
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