Neuro functional and endocrine findings in patients with post-traumatic stress disorder
Rev. med. nucl. Alasbimn j
;
11(44)apr. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-522222
ABSTRACT
The authors studied the neuro-functional findings demonstrated by SPECT in a group of 7 patients diagnosed with post traumatic stress disorder (PTSD) and their correlation with endocrinologic and clinical variables. Brain perfusion was assessed using SPECT Tc99m ECD. The Davidson Trauma Scale (DTS) for post traumatic stress disorder and the abbreviated version of the Beck Depression Inventory (BDI) were used to corroborate clinical impressions. Endocrine measures included T3, total T4, TSH and cortisol levels. Neuro-functional findings included abnormal radiopharmaceutical uptake in regions involved in the recovery of verbal memories and executive functions (frontal and pre-frontal cortex), and limbic system. No endocrine alterations affecting thyroid or cortisol levels were found. The broad distribution of neuro-functional abnormalities causes us to hypothesize a diffuse etiologic mechanism, possibly involving a dysfunction in the permeability of the blood-brain barrier due to an underlying inflammatory process.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stress Disorders, Post-Traumatic
/
Organotechnetium Compounds
/
Tomography, Emission-Computed, Single-Photon
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. med. nucl. Alasbimn j
Journal subject:
Nuclear Medicine
Year:
2009
Type:
Article
Affiliation country:
Chile
/
United States
Institution/Affiliation country:
Clinica Las Condes/CL
/
Hospital Dipreca/CL
/
Psychiatric Society of Chile/CL
/
University of California/US
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