Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata
Mem. Inst. Oswaldo Cruz
;
104(4): 649-654, July 2009. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-523735
ABSTRACT
Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiaeclinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant.
Full text:
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Index:
LILACS (Americas)
Main subject:
Saccharomyces cerevisiae
/
Benzene Derivatives
/
Candida
/
Oxidants
/
Oxidative Stress
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Potosino de Investigación Científica y Tecnológica/MX
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