Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos / Immunohistochemical expression of Ki-67 as a marker of proliferation in gallbladder mucosa samples with or without cancer
Rev. méd. Chile
;
137(7): 881-887, jul. 2009. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-527125
ABSTRACT
Background: There is paucity of knowledge on the proliferative features of normal or chronically inflamed gallbladder and the mechanisms of development of gallbladder cancer. Aim: To study the proliferation features of non tumoral gallbladder mucosa through the expression of Ki-67 antigen in tissue micro array analysis. Material and methods: The immunohystochemical expression of Ki-67 in tissue micro array was studied in 96 samples of non tumoral gallbladder mucosa (coming from 74 females aged 45±16 years and 22 males aged 53±16 years) and 102 samples of gallbladder cancer (coming from 84 females aged 62± 14 years and 18 males aged 70± 13 years). Results: The staining index of Ki-67 expression was 19±25 percent (range 096-8996) in samples of non tumoral mucosa and 46±29 percent (range 396-9896) in gallbladder cancer (p <0.01). Ki-67 was expressed in less than 10 percent of epithelial cells in 55 percent of non tumoral mucosa samples and 6 percent of gallbladder cancer samples. Seventy five percent of gallbladder cancer samples had a staining index of more than 20 percent. An expression of Ki-67 over 20 percent or 50 percent was observed in 25 percent and 15 percent of non tumoral mucosa samples, respectively Conclusions: Non tumoral gallbladder mucosa samples have a high proliferation index, measured using Ki-67 immunohystochemical expression. There is a group of samples with cellular hyper-proliferation that maybe related to the pathogenesis of gallbladder cancer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biomarkers, Tumor
/
Cell Proliferation
/
Gallbladder Neoplasms
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana de Santiago/CL
/
Hospital San Camilo/CL
Similar
MEDLINE
...
LILACS
LIS