Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile / Seroprevalence of hepatitis B virus in children with cancer under chemotherapy in 6 hospitals of Santiago, Chile
Rev. méd. Chile
;
137(7): 906-911, jul. 2009. tab
Article
in Spanish
| LILACS
| ID: lil-527129
ABSTRACT
Background:
Children under oncological therapy are at risk of infection by hepatitis B virus (HBV).Aim:
To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material andmethods:
Collaborative, multi-centric study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia, from 6 hospitals belonging to the public health network in the Metropolitan Region, between June 2004 and August 2006. These samples were stored at -70-'C. In September 2006, 200 samples were randomly chosen and 170 analyzed to determine hepatitis B virus surface antigen (HBsAg) and anticore total antibodies (anti HBc) by fluorescent ELISA (Enzyme Linked Immunosorbent Assay). In five cases in which a low volume of sample was available, only one marker was studied (HBsAg in two and anti HBc in three).Results:
Samples carne from children aged 4 months to 18 years, 104 males (61 percent). They had received an average of 38 transfusions (range 3-107) from 65 donors (range 3-345). Twelve children were found positive for some marker of HBV HBsAg in three (1.8 percent) and anti HBc in ten (7 percent). In 5 patients that had negative HBsAg and positive anti HBc, anti surface antigen antibodies (anti HBs) were determined and resulted positive in fourConclusions:
The prevalence of HBV in this sample was 7 percent if both serologic markers are considered and 1.8 percent if only HBsAg is considered.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
/
Neoplasms
/
Antineoplastic Agents
Type of study:
Controlled clinical trial
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico Universidad de Chile/CL
/
Hospital Exequiel González Cortés/CL
/
Hospital Luis Calvo Mackennna/CL
/
Hospital Roberto del Río/CL
/
Hospital San Borja Arriarán/CL
/
Hospital San Juan de Dios/CL
/
Hospital Sótero del Río/CL
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