In vitro antiplasmodial activity and toxicity assessment of plant extracts used in traditional malaria therapy in the Lake Victoria Region
Mem. Inst. Oswaldo Cruz
;
104(5): 689-694, Aug. 2009. tab
Article
in English
| LILACS
| ID: lil-528074
ABSTRACT
As part of our program screening the flora of the Lake Victoria Region, a total of 54 organic extracts from seven plant families (8 species) were individually tested for antiplasmodial activity against chloroquine-sensitive [Sierra Leone (D-6)] and chloroquine-resistant [Vietnam (W-2)] strains. Only 22 percent of these extracts exhibited very high in vitro antiplasmodial activity. Six methanol (MeOH) extracts and one chloroform extract showed in vitro antiplasmodial activity against the D-6 Plasmodium falciparum strain, while only three MeOH extracts were active against the W-2 strain. All of the ethyl acetate extracts proved to be inactive against both strains of P. falciparum. A brine shrimp cytotoxicity assay was used to predict the potential toxicity of the extracts. The cytotoxicity to antiplasmodial ratios for the MeOH extracts were found to be greater than 100, which could indicate that the extracts are of low toxicity.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plants, Medicinal
/
Plasmodium falciparum
/
Artemia
/
Plant Extracts
/
Antimalarials
Limits:
Animals
Country/Region as subject:
Africa
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Kenya
/
Rwanda
Institution/Affiliation country:
Jomo Kenyatta University of Agriculture and Technology/KE
/
Kenyatta University/KE
/
Kigali Institute of Science and Technology/RW
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