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Frequency and types of human papillomavirus among pregnant and non-pregnant women with human immunodeficiency virus infection in Recife determined by genotyping
Brandão, Vírginia da Conceição Ribes Amorim Bezerra; Lacerda, Heloisa Ramos; Lucena-Silva, Norma; Ximenes, Ricardo Arraes de Alencar.
  • Brandão, Vírginia da Conceição Ribes Amorim Bezerra; Centro Integrado de Saúde Amaury de Medeiros. Recife. BR
  • Lacerda, Heloisa Ramos; Universidade Federal de Pernambuco. Programa de Pós-Graduação em Medicina Tropical. Recife. BR
  • Lucena-Silva, Norma; Fiocruz. Centro de Pesquisa Aggeu Magalhães. Recife. BR
  • Ximenes, Ricardo Arraes de Alencar; Universidade Federal de Pernambuco. Programa de Pós-Graduação em Medicina Tropical. Recife. BR
Mem. Inst. Oswaldo Cruz ; 104(5): 755-763, Aug. 2009. graf, tab
Article in English | LILACS | ID: lil-528086
ABSTRACT
Women with human immunodeficiency virus (HIV) infection present a higher risk of infection by the human papillomavirus (HPV) and cervical cancer. To determine HPV genotypes and frequencies among HIV-positive women, an analytical cross-sectional study was carried out on 147 women (51 were pregnant and HIV-positive, 45 pregnant and HIV-negative and 51 HIV-positive and not pregnant), who were attended at a maternity hospital in Recife between April 2006-May 2007. They answered a questionnaire and underwent a gynaecological examination, with samples collected for HPV investigation by PCR, hybrid capture II, oncotic colpocytology (Papanicolau) and colposcopy. The frequency of HPV DNA was 85.3 percent (122/143), with a high proportion of HPV types that have been identified as high risk for cervical cancer. Among HIV-positive pregnant women, there was an HPV prevalence of 96 percent (48/50), of whom 60.4 percent (29/48) were high-risk. HPV 16, 58, 18, 66 and 31 were the most frequent types. Colpocytological abnormalities were observed in 35.3 percent (18/51) of HIV-positive non-pregnant women, 21.6 percent (11/51) of HIV-positive pregnant women and 13.3 percent (6/45) of HIV-negative pregnant women with a predominance of low-level lesions. A high prevalence of HPV infection was identified, especially with the high-risk types 16, 58, 18 and 66. This study identified high-risk HPV types in all three groups examined (HIV-positive pregnant women, HIV-negative pregnant women and HIV-positive not pregnant), characterising its distribution in this setting.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Papillomaviridae / Pregnancy Complications, Infectious / AIDS-Related Opportunistic Infections / Papillomavirus Infections Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Integrado de Saúde Amaury de Medeiros/BR / Fiocruz/BR / Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Papillomaviridae / Pregnancy Complications, Infectious / AIDS-Related Opportunistic Infections / Papillomavirus Infections Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Integrado de Saúde Amaury de Medeiros/BR / Fiocruz/BR / Universidade Federal de Pernambuco/BR