Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates
Mem. Inst. Oswaldo Cruz
;
104(5): 775-782, Aug. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-528089
ABSTRACT
The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C. glabrata is a haploid yeast that contains three mating-type like loci (MTL), although no sexual cycle has been described. Strains containing both types of mating information at the MTL1 locus are found in clinical isolates, but it is thought that strains containing type a information are more common. Here we investigated if a particular combination of mating type information at each MTLlocus is more prevalent in clinical isolates from hospitalized patients in Mexico and if there is a correlation between mating information and resistance to fluconazole and 5-fluorocytosine. We found that while both types of information at MTL1 are equally represented in a collection of 64 clinical isolates, the vast majority of isolates contain a-type information at MTL2 and α-type at MTL3. We also found no correlation of the particular combination of mating type information at the three MTL loci and resistance to fluconazole.
Full text:
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Index:
LILACS (Americas)
Main subject:
Fluconazole
/
Candida glabrata
/
Genes, Mating Type, Fungal
/
Flucytosine
/
Antifungal Agents
Limits:
Humans
Country/Region as subject:
Mexico
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Potosino de Investigación Científica y Tecnológica/MX
/
nstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX
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