Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on erythromycin-resistant Streptococcus suis
Braz. j. microbiol
;
40(4): 980-987, Oct.-Dec. 2009. tab
Article
in English
| LILACS
| ID: lil-528188
ABSTRACT
The postantibiotic effects (PAEs) and postantibiotic sub-MIC effects (PA SMEs) of tilmicosin, erythromycin and tiamulin on erythromycin-susceptible and erythromycin-resistant strains of Streptococcus suis (M phenotype) were investigated in vitro. Tilmicosin and tiamulin induced significantly longer PAE and PA SME against both erythromycin-susceptible and erythromycin-resistant strains than did erythromycin. The durations of PAE and PA SMEs were proportional to the concentrations of drugs used for exposure. The PA SMEs were substantially longer than PAEs on S. suis (P<0.05) regardless of the antimicrobial used for exposure. The results indicated that the PAE and PA SME could help in the design of efficient control strategies for infection especially caused by erythromycin-resistant S. suis and that they may provide additional valuable information for the rational drug use in clinical practice.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Streptococcal Infections
/
Swine
/
In Vitro Techniques
/
Drug Resistance, Microbial
/
Streptococcus suis
/
Disease Susceptibility
/
Anti-Bacterial Agents
Limits:
Animals
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2009
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Nanjing Agricultural University/CN
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