Brainstem cavernous malformations: a review with two case reports / Malformações cavernosas do tronco cerebral: uma revisão com relato de dois casos
Arq. neuropsiquiatr
;
67(3b): 917-921, Sept. 2009. ilus
Article
in English
| LILACS
| ID: lil-528659
ABSTRACT
Central nervous system (CNS) cavernous malformations (CMs) are developmental malformations of the vascular bed with a highly variable clinical course due to their dynamic nature. We present one case of "de novo" brainstem cavernous malformation after radiation therapy adding to the increasing number of reported cases in the medical literature, and the case of a pregnant patient with symptomatic intracranial hemorrhage related to brainstem CMs to illustrate the complex nature in management of these patients, followed by a review of clinical and radiographic characteristics. CMs account for 8-15 percent of all intracranial and intraspinal vascular malformations. Although traditionally thought to be congenital in origin, CMs may present as acquired lesions particularly after intracranial radiation therapy. Clinical manifestations are protean and surgical treatment should be considered for patients with progressive neurologic deficits.
RESUMO
Malformações cavernosas (MFC) do sistema nervoso central são malformações do desenvolvimento do leito vascular com múltiplas apresentações clínicas devido a sua natureza dinâmica. Apresentamos dois casos de malformações cavernosas do tronco cerebral o primeiro após radioterapia e o segundo em paciente grávida com hemorragia intracraniana sintomática. MFC são responsáveis por cerca de 8-15 por cento de todas as malformações vasculares. Embora tradicionalmente sejam genéticas, as MFC podem também ser adquiridas, particularmente após radioterapia. As manifestações clínicas são variáveis e o tratamento cirúrgico deve ser considerado para pacientes com quadros neurológicos progressivos.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pregnancy Complications, Cardiovascular
/
Brain Stem
/
Intracranial Arteriovenous Malformations
/
Cerebral Hemorrhage
Type of study:
Etiology study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2009
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Loyola University Chicago/US
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