Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice
Rev. bras. farmacogn
;
12(supl.1): 50-51, 2002. ilus
Article
in English
| LILACS
| ID: lil-528747
ABSTRACT
The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55 percent the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26 percent the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UNIFESP/BR
/
Universidade Federal de Santa Catarina/BR
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