Resultados do tratamento cirúrgico versus quimioradioterápico em tumores iniciais da orofaringe / Results of surgical treatment versus chemoradiation therapy in oropharyngeal early tumors
Arq. int. otorrinolaringol. (Impr.)
;
13(1): 34-38, jan.-mar. 2009. tab, graf
Article
in English, Portuguese
| LILACS
| ID: lil-529413
RESUMO
Introdução:
O carcinoma epidermoide na cabeça e pescoço é diagnosticado em aproximadamente 40% dos casos em estádios clínicos avançados.Objetivo:
Avaliar a sobrevida livre de doença nos pacientes com carcinoma epidermoide de orofaringe de estádio clínico (EC) precoce (I e II), submetidos ao tratamento cirúrgico ou quimioradioterápico.Método:
Estudo retrospectivo de 139 prontuários de pacientes portadores de carcinoma epidermoide de orofaringe submetidos a tratamento com intenção curativa, sendo elegíveis 38 casos de tumores de estádios clínicos precoces (I e II). Destes, 27 (71,1%) foram à cirurgia e 11 (28,9%) à quimioradioterapia, com idade média de 56,4 anos. Quanto ao gênero, 31 (81,6%) eram do masculino e sete (18,4%) do feminino.Resultados:
Nos 11 pacientes submetidos à quimioradioterapia, 72,7% obtiveram controle loco-regional da doença e a sobrevida livre de doença há dois anos foram 42%. Dentre os 27 pacientes operados, 19 mantiveram-se em EC I e II no laudo histológico e seis foram à radioterapia pós-operatória. A sobrevida livre de doença há dois anos foi 70%.Conclusão:
Os pacientes submetidos inicialmente à cirurgia tiveram melhor sobrevida livre de doença, quando comparados aos pacientes com tratamento quimioradioterápico.ABSTRACT
Introduction:
The epidermoid carcinoma of the upper aerodigestive tract is diagnosed in approximately 40% of the cases of advanced clinical stages.Objective:
To evaluate the disease-free interval in patients with clinical stages I and II epidermoid carcinoma who were submitted to surgery or chemoradiation.Method:
Retrospective study of the records of 139 patients treated for oropharyngeal epidermoid carcinoma submitted to treatment with curative intent. Among those patients, 38 were classified with early tumors clinical stages I and II. Twenty-seven (71.1%) underwent surgical treatment whereas eleven (28.9%) were treated with chemoradiation. The mean age was 56.4 years; 31 cases (81.6%) were in men and seven (18.4%) were in women.Results:
Among the eleven patients who were submitted to chemoradiation, 72.7% obtained locoregional control of the disease and their disease-free survival was of 42%. Among the 27 patients operated, 19 remained in Clinical Stages I and II in the histological report and six underwent postoperative radiation therapy. The disease-free interval for two years was of 70%.Conclusion:
The patients submitted to the surgery had a better disease-free interval as compared to those submitted to chemoradiation treatment.
Full text:
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Index:
LILACS (Americas)
Main subject:
Carcinoma, Squamous Cell
/
Oropharyngeal Neoplasms
/
Early Diagnosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Arq. int. otorrinolaringol. (Impr.)
Journal subject:
Otolaryngology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Lusíada/BR
/
Hospital Heliópolis/BR
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