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Treatment of cutaneous tumors with topical 5 percent imiquimod cream
Alessi, Sabrina Sisto; Sanches, Jose Antonio; Oliveira, Walmar Roncalli de; Messina, Maria Cristina; Pimentel, Eugenio Raul de Almeida; Festa Neto, Cyro.
  • Alessi, Sabrina Sisto; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
  • Sanches, Jose Antonio; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
  • Oliveira, Walmar Roncalli de; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
  • Messina, Maria Cristina; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
  • Pimentel, Eugenio Raul de Almeida; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
  • Festa Neto, Cyro; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Dermatology Department. São Paulo. BR
Clinics ; 64(10): 961-966, 2009. tab
Article in English | LILACS | ID: lil-529538
ABSTRACT

INTRODUCTION:

There are various approaches to the treatment of cutaneous tumors; one of them is treatment with imiquimod, a synthetic toll-like receptor agonist with a low molecular weight that offers a topical, noninvasive, and non-surgical therapeutic option. The main objective of our study was to provide data on 89 patients who used a 5 percent imiquimod cream for the treatment of cutaneous tumors at the Cutaneous Oncology Group of the Dermatology Department of Hospital das Clinicas from 2003 to 2008. MATERIALS AND

METHODS:

Here, we present our experience in the treatment of 123 cutaneous tumors of various types, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen's disease, erythroplasia of Queyrat, Paget's disease, and trichoepithelioma, with 5 percent imiquimod cream from 2003 to 2008 in the Cutaneous Oncology Group of the Dermatology Department of Hospital das Clinicas. Patients were divided into two separate groups according to their diagnosis and comorbidities; these comorbidities included epidermodysplasia verruciformis, xeroderma pigmentosum, albinism, basal cell nevus syndrome, Brooke-Spiegler syndrome, HIV, chronic lymphocytic leukemia, B-cell lymphoma, and kidney transplantation. Treatment duration, response to imiquimod, follow-up, recurrence, and local and systemic reactions associated with use of the drug were analyzed. Epidemiological data were obtained and cure rates were calculated.

RESULTS:

The ratio of women to men was 1.281, and the mean age was 63.1 years. Tumors were located mainly on the face, back, trunk, and legs. For patients with comorbidities, the overall cure rate was 38 percent. These specific patients demonstrated cure rates of 83.5 percent for superficial BCC and 50 percent for Bowen's disease. Aggressive BCC and superficial and nodular BCC did not present a good response to treatment. Trichoepitheliomas and nodular BCC showed a partial response, and erythroplasia of Queyrat showed ...
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Adjuvants, Immunologic / Aminoquinolines / Antineoplastic Agents Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Adjuvants, Immunologic / Aminoquinolines / Antineoplastic Agents Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2009 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR