Single lesion leprosy pacients multicentric cohort treated with single dose drug therapy: findings on three year follow up and public health perspective in Brazil
Cad. saúde colet., (Rio J.)
;
16(2): 363-376, abr.-jun. 2008. tab, graf
Article
in English
| LILACS
| ID: lil-529797
ABSTRACT
Single skin lesion, paucibacillary (SSL PB) leprosy is considered an early disease manifestation. This study evaluated the clinical outcome of a cohort of 259 newly diagnosed SSL PB treated with one dose of rifampicin, ofloxacin, minocycline (ROM) and followed up three years. Patients were recruited from the North, Central West and Southeast regions in Brazil (1997-2001). The result expected with ROM therapy was disappearance or the reduction of lesion size. Manifestations that required additional intervention were considered as poor clinical outcome:
type 1 reaction (T1R) with or without neuritis, neuritis alone, increase in lesion size and shift from paucibacillary to multibacillary. The incidence of poor clinical outcome was calculated by person month and with the Kaplan Meier methods. 61,8 percent of the participants were females, mean age 32.2 and 67,2 percent had borderline tuberculoid (BT) or tuberculoid forms. TIR was the predominant event; shift from paucibacillary to multibacillary was rare. 92 percent of the volunteers shown no events during the first year, the same occurring to 80,6 percent of them after 3 years of clinical monitoring. The probability of remaining event free was highest among those 40 years old or younger. Poor outcome predominated among BT patients. Extended monitoring of SSL PB leprosy cases under minimal therapy provided valuable case management information for reference centers.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Leprosy
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Cad. saúde colet., (Rio J.)
Journal subject:
Public Health
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação de Dermatologia Tropical e Venereologia Alfredto da Matta/BR
/
Hospital Clínica Grajaú/BR
/
Hospital Doutor Marcello Cândia/BR
/
Instituto Oswaldo Cruz/BR
/
Universidade Federal de Goiás/BR
/
Universidade Federal do Rio de Janeiro/BR
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