Estado actual de la terapia antiangiogénica en el manejo de gliomas de alto grado / Present state of the antiangiogenic therapy in the management of gliomas of high degree
Rev. Hosp. Clin. Univ. Chile
;
19(3): 239-244, 2008. tab, ilus
Article
in Spanish
| LILACS
| ID: lil-530342
ABSTRACT
High grade gliomas are lethal cancers. Despite recent advances in surgery, radiotherapy and chemotherapy, the overall survival is 15 months for glioblastoma. They are among the most vascular of human tumors, making them especially attractive targets for angiogenesis inhibitors. Most clinical trials of these agents as monotherapy have failed to demonstrate survival benefit in unselected high grade glioma patient populations. Several mechanisms of treatment failure have been postulated. In response, there are new intervention strategies on course the combination of target therapy with classic chemotherapy, multitargeted kinase inhibitors and combinations of single-targeted kinase inhibitors and the identification of correlative biomarkers. These advances provide real opportunities for the development of effective therapies for high grade gliomas.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Angiogenesis Inhibitors
/
Glioma
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. Hosp. Clin. Univ. Chile
Journal subject:
Medicine
Year:
2008
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Roberto del Río/CL
/
Universidad de Chile/CL
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