Evaluación genotóxica del D-004, extracto del fruto de Roystonea regia, mediante el ensayo de micronúcleos / Genotoxic assessment of D-004, extract from Roystonea regia fruit, by means of micronuclei assays
Rev. cuba. farm
;
43(2)mayo-ago. 2009.
Article
in Spanish
| LILACS
| ID: lil-531359
RESUMEN
El D-004 es un extracto lipídico del fruto de la palma real (Roystonea regia), que ha demostrado ser eficaz en prevenir la hiperplasia prostßtica inducida por testosterona y por fenilefrina en modelos experimentales en ratas. El objetivo fue determinar si el D-004 induce cambios en la frecuencia de aparición de micronúcleos al realizar la administración oral a dosis repetida durante 8 semanas. Se formaron 5 grupos experimentales (7 animales/grupo) un grupo control solvente, tres tratados con D-004 (500, 1 000 y 1 500 mg/kg) y un control positivo tratado con ciclofosfamida. No ocurrieron muertes ni se detectaron signos clínicos de toxicidad. No hubo diferencias significativas entre controles y tratados en cuanto a la frecuencia de eritrocitos policromatófilos micronucleados y el índice de citotoxicidad. En conclusión, el D-004 administrado por vía oral a las dosis empleadas no presenta actividad clastogénica ni citotóxica en médula ósea de ratones OF-1 machos in vivo.
ABSTRACT
D-004 is a lipid extract from the real palm fruit (Roystonea regia), which has demonstrated that is effective to prevent prostatic hyperplasia from testosterone and from phenylephrine in rats' experimental models. Aim of this paper was to determine if D-004 provoke changes in appearance frequency of micronuclei during oral administration of repeated doses for 8 weeks. Five experimental groups were created (7animals/group) a solvent control-group, three treated with D-004(500, 1 000, and 1 500 mg/kg), and a positive control-group treated with cyclophosphamide. There were no deaths or clinical signs of toxicity neither significant differences among controls and treated ones as regards the frequency of micronucleated polychromatophils erythrocytes, and the cytotoxic index. In conclusion, D-004 administered per os at doses used has neither clastogenic nor cytotoxic activity in bone marrow male OF-1mice in vivo.
Full text:
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Index:
LILACS (Americas)
Main subject:
Prostatic Hyperplasia
/
Micronucleus Tests
/
Erythrocytes
/
Fat Emulsions, Intravenous
Type of study:
Prognostic study
Limits:
Animals
Language:
Spanish
Journal:
Rev. cuba. farm
Journal subject:
Pharmacy
Year:
2009
Type:
Article
Affiliation country:
Cuba
Institution/Affiliation country:
Centro de Productos Naturales/CU
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