Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
Electron. j. biotechnol
;
11(4): 2-3, Oct. 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-531932
ABSTRACT
Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (+/-)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
Full text:
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Index:
LILACS (Americas)
Main subject:
Bacteria, Aerobic
/
Biologic Oxidation
/
Bioreactors
/
Methanol
/
Gram-Positive Bacteria
Language:
English
Journal:
Electron. j. biotechnol
Journal subject:
Biotechnology
Year:
2008
Type:
Article
/
Project document
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad Autónoma Metropolitana/MX
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