CD40, autophagy and Toxoplasma gondii
Mem. Inst. Oswaldo Cruz
;
104(2): 267-272, Mar. 2009. ilus
Article
in English
| LILACS
| ID: lil-533516
ABSTRACT
Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles. The dogma had been that the non-fusogenic nature of these vacuoles is irreversible. Recent studies revealed that this dogma is not correct. Cell-mediated immunity through CD40 re-routes the parasitophorous vacuoles to the lysosomal compartment by a process called autophagy. Autophagosome formation around the parasitophorous vacuole results in killing of the T. gondii. CD40-induced autophagy likely contributes to resistance against T. gondii particularly in neural tissue.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Autophagy
/
Toxoplasma
/
Toxoplasmosis
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
University School of Medicine/US
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