In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
104(7): 980-985, Nov. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-534162
ABSTRACT
The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50 0.6 ìM) against epimastigotes.
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Nitro Compounds
/
Antiprotozoal Agents
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Chile
/
Costa Rica
Institution/Affiliation country:
Universidad Austral de Chile/CL
/
Universidad Nacional/CR
/
Universidad de Costa Rica/CR
/
Universidad de Santiago de Chile/CL
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