Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
Mem. Inst. Oswaldo Cruz
;
104(7): 1009-1011, Nov. 2009.
Article
in English
| LILACS
| ID: lil-534167
ABSTRACT
Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7 percent) and double (14.3 percent) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2 percent) and triple (42.8 percent) mutant haplotypes. The implications of these findings are discussed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plasmodium vivax
/
Insecticide Resistance
/
Protozoan Proteins
/
Genes, Protozoan
/
Multidrug Resistance-Associated Proteins
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Evandro Chagas/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
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