Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula
Mem. Inst. Oswaldo Cruz
;
104(7): 1035-1038, Nov. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-534172
ABSTRACT
The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 ìM against G. truncatula).
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plants, Medicinal
/
Snails
/
Plant Extracts
/
Alkaloids
/
Isoquinolines
/
Molluscacides
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Tunisia
Institution/Affiliation country:
Faculty of Medicine/TN
/
Faculty of Science/TN
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