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Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula
Mezghani-Jarraya, R; Hammami, H; Ayadi, A; Damak, M.
  • Mezghani-Jarraya, R; Faculty of Science. Laboratory of Natural Substances Chemistry. TN
  • Hammami, H; Faculty of Medicine. Fungal and Parasitic Molecular Biology Laboratory. TN
  • Ayadi, A; Faculty of Medicine. Fungal and Parasitic Molecular Biology Laboratory. TN
  • Damak, M; Faculty of Science. Laboratory of Natural Substances Chemistry. TN
Mem. Inst. Oswaldo Cruz ; 104(7): 1035-1038, Nov. 2009. ilus, tab
Article in English | LILACS | ID: lil-534172
ABSTRACT
The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 ìM against G. truncatula).
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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Snails / Plant Extracts / Alkaloids / Isoquinolines / Molluscacides Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Tunisia Institution/Affiliation country: Faculty of Medicine/TN / Faculty of Science/TN

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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Snails / Plant Extracts / Alkaloids / Isoquinolines / Molluscacides Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Tunisia Institution/Affiliation country: Faculty of Medicine/TN / Faculty of Science/TN